Positively charged patches: tonic for CAR fitness

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Consequences of CAR T-cell therapy in OC. The Figure shows the antigens

Volume 33 Issue 5, May 2023

PDF] Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Model for Counterion Binding and Charge Reversal on Protein Surfaces

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

The persistence and antitumor efficacy of CAR-T cells are modulated by tonic signaling within the CDR - ScienceDirect

Soluble expression of proteins correlates with a lack of positively-charged surface

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Model for Counterion Binding and Charge Reversal on Protein Surfaces

The persistence and antitumor efficacy of CAR-T cells are modulated by tonic signaling within the CDR - ScienceDirect

Soluble expression of proteins correlates with a lack of positively-charged surface